发明名称 |
Enhanced immunogenic cell populations prepared using H2 receptor antagonists |
摘要 |
This invention provides a method to enhance alloactivation in a mixed lymphocyte culture. Alloactivated cells are effective in treating tumors when implanted into a tumor site or coinjected with tumor cells as a vaccine. By enhancing alloactivation, more cell combinations achieve a threshold of activation adequate for use in therapy, and the level of cytokine secretion in proliferative phase cultures is generally increased.
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申请公布号 |
US6368593(B1) |
申请公布日期 |
2002.04.09 |
申请号 |
US19980169345 |
申请日期 |
1998.10.09 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
THOMPSON JAMES A. |
分类号 |
A61K38/00;C12N5/0783;(IPC1-7):A01N63/00;C12N5/06;C12N5/08;C12N5/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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