| 发明名称 |
PROCESS FOR PREPARING OLOPATADINE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF |
| 摘要 |
The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt. |
| 申请公布号 |
HUE028705(T2) |
申请公布日期 |
2016.12.28 |
| 申请号 |
HUE10705320 |
申请日期 |
2010.02.01 |
| 申请人 |
ZaCh System S.p.A. |
发明人 |
GUIDI, Alberto;CHIARELLO, Filippo;ORRU', Gianmauro;VERZINI, Massimo;COTARCA, Livius;KIZIRIAN, Jean-Claude;TREPAT GUIXER, Elisenda;MARQUILLAS OLONDRIZ, Francisco |
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