| 摘要 |
PURPOSE: Provided is a method for preparing higher purity (S)-2-(6'-methoxy-2'-naphthyl)propionic acid in higher yields than existing method. CONSTITUTION: The method, which is for preparing optical pure (S)-2-(6'-methoxy-2'-naphthyl)propionic acid of formula 3 and its derivative, comprises Grignard reacting a compound of formula 1 with a compound of formula 2. In the formulae, X represents halogen such as bromine, iodine, and chlorine, or -SO2R'(wherein, R' represents a methyl, an ethyl, paratoluene, benzene, paranitrobenzene); and L represents a methyl, or an ethyl; or sodium or potassium. The reaction temperature is -30 to 100 deg.C.
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