CATALYTIC HYDROGENATION OF NITRILES

摘要

The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluorometyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluorometyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

主权项

1. A process (A) for preparing a substituted 2-ethylaminopyridine derivative of formula (III) and/or a corresponding salt thereof, Wherein p is an integer equal to 1, 2, 3 or 4; each substituent X is chosen, independently of the others, as being halogen, C1-C4 alkyl or C1-C4 haloalkyl; comprising in (A1), hydrogenating a substituted 2-methyl cyanopyridyl derivative according to formula (II) wherein p is an integer equal to 1, 2, 3 or 4; each substituent X is chosen, independently of the others, as being halogen, C1-C4 alkyl or C1-C4 haloalkyl; in the presence of a metal catalyst, a catalyst modifier, and an acid.