| 发明名称 |
Genetically engineered cell culture adapted infectious bursal disease virus (IBDV) mutants |
| 摘要 |
The present invention relates to a method for the adaptation of infectious bursal disease viruses (IBDV) to growth in CEF cell culture. Changing the codons for amino acid residues 253 (Gln) and 284 (Ala) to 253 (His) and 284 (Thr) allowed bursa adapted Classical and Variant-E IBDV to grow in CEF cell culture. For GLS IBDV only a change of the codon for amino acid residue 284 was necessary.
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| 申请公布号 |
US6492148(B1) |
申请公布日期 |
2002.12.10 |
| 申请号 |
US20000513487 |
申请日期 |
2000.02.25 |
| 申请人 |
AKZO NOBEL NV |
发明人 |
VAN LOON ADRIAAN ANTONIUS WILHELMUS MARIA;MUNDT EGBERT |
| 分类号 |
C12N15/09;A61K39/12;A61P31/12;C07K14/08;C12N5/10;C12N7/00;C12N15/00;C12N15/01;C12N15/12;C12P21/02;(IPC1-7):A01N63/00 |
主分类号 |
C12N15/09 |
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