发明名称 METHOD FOR APPLYING GENETIC THERAPY OF VASCULAR DISEASES BY MEANS OF ACTIVE SUBSTANCE SPECIFIC TO CELL AND DEPENDANT ON CELLULAR CYCLE
摘要 FIELD: medicine. SUBSTANCE: method involves applying DNA structure which essential element is activating sequence, proportion modulus and active substance gene. The activating sequence is excited in cell- specific way in smooth muscle cells, activated endothelium cells, activated macrophages or activated lymphocytes. This activation process is cell cycle-specifically controlled by promotion modulus. The active substance is a smooth muscle cells growth inhibitor and/or blood coagulation inhibitor. The described DNA- sequence is inserted into virus or non-virus vector completed with a ligand agent possessing affinity to target cell. EFFECT: enhanced effectiveness of treatment. 34 cl, 11 dwg
申请公布号 RU2197992(C2) 申请公布日期 2003.02.10
申请号 RU19970104482 申请日期 1995.08.25
申请人 KH¿KHST AG 发明人 SEDLACHEK KHANS-KHARAL'D;MJULLER ROL'F
分类号 A61K48/00;C07K;C12N;C12N15/11;C12N15/86 主分类号 A61K48/00
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