Peptide linkers for covalent linking polypeptide cell modulators

摘要

Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities. Also described is a peptide linker segment comprising a mouse IgG gamma 2b "hinge" in which the four cysteines of the "hinge" have been converted to serines.