NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS.

摘要

There is provided compounds of formula I, wherein Y and R<1> have meanings given in the description, and pharmaceutically acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.