| 发明名称 |
METHOD OF TREATING DOPAMINERGIC AND GABA-NERGIC DISORDERS |
| 摘要 |
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.
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| 申请公布号 |
US2003119729(A1) |
申请公布日期 |
2003.06.26 |
| 申请号 |
US19990451939 |
申请日期 |
1999.12.01 |
| 申请人 |
MIAO NINGNING;WANG MONICA;MAHANTHAPPA NAGESH K.;JIN PING;PANG KEVIN |
发明人 |
MIAO NINGNING;WANG MONICA;MAHANTHAPPA NAGESH K.;JIN PING;PANG KEVIN |
| 分类号 |
C12N15/09;A61K31/00;A61K31/47;A61K31/472;A61K31/496;A61K31/55;A61K31/553;A61K31/7076;A61K31/711;A61K38/00;A61K45/00;A61K48/00;A61P25/14;A61P25/16;A61P43/00;C07D217/02;C07D401/12;C07H21/04;C07K14/46;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N15/12;C12Q1/68;(IPC1-7):A61K38/17;A61K31/655 |
主分类号 |
C12N15/09 |
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