| 摘要 |
The present invention relates to proteins associated with T cell activation, termed TCAPs (T Cell Activation-associated Proteins), TCAP-encoding genes and nucleic acid derived therefrom, and methods for identifying TCAP-encoding genes. The method provides amino acid sequences of the TCAPs TA-GAP, TA-GPCR, TA-PP2C, TA-NFKBH, TA-KRP, TA-WDRP, and TA-LRRP, and nucleotide sequences of the genes encoding them, and nucleic acid derived therefrom, as well as amino acid and nucleic acid derivatives (e.g., fragments) thereof. The invention further relates to fragments (and derivatives thereof) of particular TCAPs that comprise one or more domains of a TCAP. Antibodies to TCAPs, and to TCAP derivatives, are additionally provided. Methods of production of the TCAPs, derivatives, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated TA-GAP, TA-GPCR, TA-PP2C, TA-NFKBH, TA-KRP, TA-WDRP, and TA-LRRP genes from human, and the sequences thereof, are provided.
|
