发明名称 |
COMPOSITE ANTIBODIES OF HUMAN SUBGROUP IV LIGHT CHAIN CAPABLE OF BINDING TO TAG-72 |
摘要 |
<p>This invention concerns a subset of composite Hum4 VL, VH alpha TAG antibody with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) VL segments derived from the human subgroup IV germline gene and (2) a VH segment which is capable of combining with the VL to form a three dimensional structure having the ability to bind TAG-72. in vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.</p> |
申请公布号 |
EP0618969(B1) |
申请公布日期 |
2003.06.25 |
申请号 |
EP19920901213 |
申请日期 |
1991.12.13 |
申请人 |
THE DOW CHEMICAL COMPANY |
发明人 |
MEZES, PETER, S.;RICHARD, RUTH, A.;JOHNSON, KIM, S. |
分类号 |
A61K38/00;A61K51/10;C07K16/30;C07K16/46;C12N15/13;(IPC1-7):C12N15/13;A61K47/48;C12N5/10;A61K39/395;A61K49/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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