| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound which is a specific azolylamine derivative containing an azolyl group and an amine ring in the molecule, has strongly antimicrobial activity, low toxicity and is effective for preventing and treating human and animal fungal diseases. SOLUTION: This azolylamine derivative is shown by formula I [Ar is a (substituted) phenyl; R<1> and R<2> are each H, a lower alkyl, a (substituted) aryl, an alkenyl, an alkynyl or an aralkyl; (m) is 2 or 3; (n) is 1 or 2; X is N or CN; * is an asymmetric carbon atom]. The azolylamine derivative has strongly antifungal activity, low toxicity and is effective for preventing and treating human and animal fungal diseases. The compound is obtained by reacting an azolyl group-containing epoxy compound of formula II e.g. (2R,3S)-2-(2,4- difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methylloxirane, etc.} with a cyclic amine of formula III (e.g. 4-methylpiperidine, etc.). |
