Method for identification of mutant antigens with enhanced immunogenicity

摘要

A method is provided for identifying mutant antigens with enhanced immunogenicity that does not depend on any a priori knowledge of the structure of the native antigen. Antigens identified in this way may be used to induce an immune response to a target antigen in a subject comprising administering to the subject a vaccine composition comprising the mutant antigen corresponding to the target antigen in an amount sufficient to induce an immune response to the target antigen. The target antigen may be a self-antigen.