| 摘要 |
FIELD: medicine, oncology. SUBSTANCE: invention elates to agent for fluorescent diagnosis and photodynamic therapy based on using 5-aminolevulinic acid hydrochloride as a prosensitizing agent. Agent represents 5-aminolevulinic acid hydrochloride immobilized on biosoluble polymer that comprises a mixture of hydrophilic and lipophilic modifying components and a taste supplement. Agent represents buccal plate of the following composition, wt. -%: 5- aminolevulinic acid hydrochloride, 31-55; biosoluble polymer, 35-50; lipophilic component, 3-11; hydrophilic component, 2-8; taste supplement, 3-6. As a biosoluble polymer copolymer of vinylpyrrolidone, ethyl acrylate and acrylamide is used that is characterized by ratio of the parent monomers, wt.-% = 20:20:60, respectively, and molecular mass 200 000 1 000 000 Da. As a lipophilic addition the dispersions of hydrogenated fats, menthol oil, cacao oil or their mixtures are used. As a hydrophilic addition glycerol or polyethylene oxide with molecular mass 600- 4 000 Da or their mixtures are used. As taste supplements saccharin, calcium succaryl, aspartam or their mixtures are used. Proposed agent provides transmucose transport of 5-aminilevulnic acid hydrochloride in arterial and lymphatic systems of body that promotes to its selectivity for neoplasms in significant reducing its concentration in normal tissues, effectiveness of diagnosis and PhDTh. EFFECT: enhanced effectiveness and valuable medicinal properties of agent. 5 cl, 8 ex
|
