ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ N-ФЕНИЛ-2-ГИДРОКСИ-2-МЕТИЛ-3,3,3-ТРИФТОРПРОПАНАМИДА, ПОВЫШАЮЩИЕ АКТИВНОСТЬ ПИРУВАТДЕГИДРОГЕНАЗЫ

摘要

A compound of formula (I) wherein: n is 1 or 2; R<1 >is chloro, fluoro, bromo, methyl or methoxy; R<2 >is as defined within; R<3 >is as defined within; and R<4 >is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.