| 摘要 |
<p>The invention relates to compounds of the general formula wherein R1 is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, -S-lower alkyl, -S(O)2-lower alkyl, -N(R)-(CH2)n-N(R)2, -O-(CH2)n-N(R)2, or a cyclic tertiary amine which may contain one additional heteroatom, selected from N, O or S, and wherein this group may be connected with the pyrimidine ring via the linker -O-(CH2)n-; R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R3/R3' is, independently from each other, hydrogen or lower alkyl; R4 is independently from each other halogen, trifluoromethyl or lower alkoxy, R5 is hydrogen or lower alkyl, R is independent from any other hydrogen or lower alkyl, X is -C(O)N(R) or -N(R)C(O)-, Y is -O-, -S-, -SO2-, -N(R)-; n is 1, 2, 3 or 4; and to pharmaceutically acceptable acid addition salts thereof. They have a good affinity to the NK1 receptor and they are therefore suitable in the treatment of diseases, related to this receptor. 25 claims</p> |
