PROSTAGLANDIN DERIVATIVE AND DRUG COMPRISING THE SAME DERIVATIVE AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To provide a prostaglandin derivative, its nontoxic salt or a cyclodextrin clathrate compound thereof or a drug comprising the same as an active ingredient. SOLUTION: The prostaglandin derivative is represented by general formula (I) (wherein, Z1, Z2and Z3denote each a specific group). The compound represented by general formula (I) is extremely useful for prophylaxis and/or treatment of osteopenia (osteopathy such as primary osteoporosis, secondary osteoporosis, cancer bone metastasis, hypercalcemia, Paget's disease, bone deficiency or osteonecrosis, osteogenesis after bone surgery or bone transplanting alternative therapy). COPYRIGHT: (C)2004,JPO