| 摘要 |
FIELD: medicine; biotechnology.SUBSTANCE: disclosed is use of a dumbbell-shaped linear, covalently closed DNA expression construct with a double-stranded stem and single-stranded loops located at both ends of stem, wherein stem of complementary deoxyribonucleic acids of a circular DNA strand comprises a promotor sequence, a coding sequence and a termination signal, where DNA construct codes TNF-α, for treating melanoma, wherein said DNA construct is administered by jet injection, and said construct is administered simultaneously or successively with vindesine.EFFECT: use of said DNA construct significantly enhances vindesine action.5 cl, 7 dwg, 1 tbl |
