摘要 |
<p>A method for the preparation of citalopram is described comprising reaction of a compound of formula (IV) wherein R1 is H or C1-6alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-halogen-N,N- dimethylpropylamine, effecting ring closure of the resulting compound of formula (VI) and converting the resulting 1,3-dihydroisobenzofuran compound to the corresponding 5-cyano derivative, i.e. citalopram.</p> |