发明名称 |
Synthesis of ruthenium-hydride complexes and preparation procedures of chiral alcohols and ketones |
摘要 |
trans-RuH(eta<1>-BH4)[(S)-xylbinap][(S,S)-dpen] (0.00125 mmol), acetophenone (5.0 mmol), and 2-propanol (2.5 mL) were placed in an autoclave, and the resulting solution was repeatedly subject 5 times to a procedure of performing pressure reduction and argon introduction while stirring the solution for deaeration. A hydrogen tank was then connected to the autoclave, and after replacing the air inside an introduction tube with hydrogen, the pressure inside the autoclave was adjusted to 5 atmospheres and then hydrogen was released until the pressure dropped to 1 atmosphere. After repeating this procedure 10 times, the hydrogen pressure was adjusted to 8 atmospheres and stirring at 25° C. was performed for 12 hours. By concentrating the solution obtained by depressurization and subjecting the crude product to simple distillation, (R)-1-phenylethanol (yield: 95%) in the form of a colorless oily substance was obtained at an ee of 99%.
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申请公布号 |
US6720439(B1) |
申请公布日期 |
2004.04.13 |
申请号 |
US20020291611 |
申请日期 |
2002.11.12 |
申请人 |
NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE |
发明人 |
OHKUMA TAKESHI;KOIZUMI MASATOSHI;MUNIZ KILIAN;NOYORI RYOJI |
分类号 |
B01J31/12;B01J31/18;B01J31/24;C07B41/02;C07B53/00;C07B61/00;C07C29/145;C07C33/03;C07C33/22;C07C35/08;C07C41/26;C07C41/44;C07C43/196;C07C45/85;C07C49/403;C07C67/31;C07C67/56;C07C69/732;C07C69/84;C07C211/27;C07C213/00;C07C215/30;C07D301/00;C07D301/32;C07D303/22;C07D303/26;C07D317/24;C07F9/50;C07F15/00;(IPC1-7):C07F15/00;B01J31/00;B01D3/34;C07C29/14 |
主分类号 |
B01J31/12 |
代理机构 |
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地址 |
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