GOLD ION BEAM DRILLED NANOPORES MODIFIED WITH THIOLATED DNA ORIGAMIS

摘要

A nanopore structure includes an aperture extending from a first surface to a second surface of a substrate, the aperture having a wall comprising gold ions embedded in the substrate, the wall defining a first diameter; a first deoxyribonucleic acid (DNA) layer including a thiolated DNA strand covalently bonded to the embedded gold ions within the wall of the aperture; and a second DNA layer hydrogen bonded to the first DNA layer, the second DNA layer defines a substantially cylindrical nanopore that defines a second diameter within the wall of the aperture, the second DNA layer including a single-stranded DNA strand; wherein the second diameter is less than the first diameter.

主权项

1. A method for making a nanopore structure, the method comprising:
drilling with a gold ion beam to define an aperture through a substrate and to introduce and embed gold ions within a wall of the aperture, the wall defining a first diameter; embedding the gold ions in a region confined to the wall of the aperture to a thickness of about 2 to about 40 nm; bonding a thiolated DNA strand to the embedded gold ions with covalent bond; and bonding a single-stranded DNA strand to the thiolated DNA strand with a hydrogen bond to define a substantially cylindrical nanopore, the substantially cylindrical nanopore defining a second diameter within the aperture; wherein the second diameter is less than the first diameter.