发明名称 |
Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities |
摘要 |
Fc fusion proteins of human G-CSF with increased biological activities relative to rhG-CSF on a molar basis are disclosed. The hG-CSF-L-vFc fusion protein comprises hG-CSF, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such hG-CSF-L-vFc fusion proteins exhibit extended serum half-life and increased biological activities, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time.
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申请公布号 |
US2004259209(A1) |
申请公布日期 |
2004.12.23 |
申请号 |
US20040800497 |
申请日期 |
2004.03.15 |
申请人 |
SUN LEE-HWEI K.;SUN BILL N. C.;SUN CECILY R. Y. |
发明人 |
SUN LEE-HWEI K.;SUN BILL N. C.;SUN CECILY R. Y. |
分类号 |
C07K14/535;(IPC1-7):C07K14/535;C07H21/04;C12P21/04 |
主分类号 |
C07K14/535 |
代理机构 |
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地址 |
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