| 发明名称 |
СПОСОБ ПОЛУЧЕНИЯ (3-ЦИАНО-1H-ИНДОЛ-7-ИЛ) (4-ФТОРФЕНЕТИЛ)-ПИПЕРАЗИН-1-ИЛ) МЕТАНОНА И ЕГО СОЛЕЙ |
| 摘要 |
The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product. |
| 申请公布号 |
RU2003124068(A) |
申请公布日期 |
2005.01.10 |
| 申请号 |
RU20030124068 |
申请日期 |
2001.12.21 |
| 申请人 |
МЕРК ПАТЕНТ ГМБХ (DE) |
发明人 |
Элен КРАССЬЕ (DE);Уве ЭККЕРТ (DE);Хеннинг БЁТТХЕР (DE);Андреас БАТЭ (DE);Штеффен ЭММЕРТ (DE) |
| 分类号 |
A61K31/496;A61P1/14;A61P7/02;A61P9/00;A61P9/06;A61P25/00;A61P25/04;A61P25/20;A61P25/22;A61P25/30;A61P27/06;A61P39/02;A61P43/00;C07D209/14;C07D209/30;C07D209/42;C07D211/78 |
主分类号 |
A61K31/496 |
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