| 摘要 |
FIELD: medicine, immunology, pharmacology. ^ SUBSTANCE: immunogenicity is enhanced by fusion of preliminary taken antigen with the immunoglobulin heavy chain constant region for preparing the fused protein Fc-antigen. Fused proteins Fc-antigen are bound by receptors for Fc on surface antigen-representing cells and providing the target direction of antigen to antigen-representing cells. Also, invention discloses family of adjuvants. For example, invention describes the fused protein Fc-adjuvant for using in combination with fused proteins Fc-antigen to enhance or to modulate the specific immune response to preliminary taken antigen. Invention provides expanding assortment of agents used for stimulation of immunity. ^ EFFECT: valuable biological and medicinal properties of fused proteins. ^ 27 cl, 14 dwg, 1 tbl, 11 ex |
