| 主权项 |
1. A compound of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein: L1 is independently L4-O or O-L4; L2 is independently a hydrocarbon linker substituted with 0-2 Rc, a hydrocarbon-heteroatom linker substituted with 0-2 Rc, or —(CH2)1-2—(C3-4 cycloalkyl substituted with 0-2 Rc)—(CH2)0-1—; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, —CO—, S, —SO—, —SO2—, NH, N(C1-4 alkyl), —CONH—, and —NHCO—; L4 is independently a bond or a hydrocarbon linker; wherein said hydrocarbon linker has one to four carbon atoms and may be straight or branched; R1 is independently selected from: C6-10 carbocycle and a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p; wherein said carbocycle and heterocycle are substituted with 0-4 R3 and 0-1 R4; R2 independently selected from: OH, CO2H, CO2(C1-4 alkyl), CONReRf, and —CONHSO2Rf; R3, at each occurrence, is independently selected from: halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 haloalkylthio, and NO2; R4 is independently -L3-R5; L3 is independently selected from: a bond, O, and C(═O); R5 is independently selected from: phenyl and a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S(O)p; wherein each ring moiety is substituted with 0-2 Ra; Ra, at each occurrence, is independently selected from: halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl; Rb, at each occurrence, is independently selected from: H, C1-4 alkyl, and —(CH2)0-2-(phenyl substituted with 0-3 Rd); Rc, at each occurrence, is independently selected from: ═O, halogen, OH, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy; Rd, at each occurrence, is independently selected from: halogen, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl; Re, at each occurrence, is independently selected from: H and C1-4 alkyl; Rf, at each occurrence, is independently selected from: H, C1-4 alkyl, —(CH2)0-2-phenyl, and C3-6 cycloalkyl substituted with 1-2 OH; Re and Rf may be combined with the nitrogen atom to which they are attached to form a 4- to 6-membered heterocyclic ring comprising carbon atoms and 1 additional heteroatom selected from N, NRb, O, and S; wherein said heterocycle is substituted with and 0-1 OH; and p is, independently at each occurrence, selected from 0, 1, and 2. |
