MANGANESE AND IRON BASED COMPOUNDS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT

摘要

The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereo f, suitable in facilitating synthesis and deposition of connective tissue matri x, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferatio n of these cell types. The present invention also describes methods of treatme nt of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.