发明名称 |
[3-AMINO]-TETRAHYDROCARBAZOLE-PROPANOIC ACID ESTERS |
摘要 |
The invention relates to new [3-amino]- tetrahydrocarbazole-propanoic acid esters which can be used as intermediates for the preparation of known thromboxane- antagonistic active compounds, and to a method for the purification of these active compounds. The new compounds have the general formula (I): (see formula I) wherein R represents C1-10-alkyl, or a salt thereof. Also provided are processes for preparing the compound (I), comprising: a) reacting a tetrahydrocarbazole of the formula (II) (see formula II) in which R1 represents hydrogen or methyl, and Aryl represents naphthyl or phenyl, with an acrylic ester of the formula (III) H2C=CH-COOR (III) and subsequently removing the group -CH(R1)-Aryl; or b) reacting a tetrahydrocarbazole of the formula (IV) (see formula IV) with an acrylic ester of formula (III) as defined above.
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申请公布号 |
CA2170223(C) |
申请公布日期 |
2005.10.25 |
申请号 |
CA19962170223 |
申请日期 |
1996.02.23 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
SAMAAN, SAMIR;LANZ, JOACHIM;NAAB, PAUL;ROSENTRETER, ULRICH |
分类号 |
C07D209/88;(IPC1-7):C07D209/88 |
主分类号 |
C07D209/88 |
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地址 |
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