| 摘要 |
N-(Substituted alkyl)-2-(heteroarylsulfonyl-amino)-benzamide derivatives (I) and their salts, are new. N-(Substituted alkyl)-2-(heteroarylsulfonyl-amino)-benzamide derivatives of formula (I) and their salts, are new: R1 = -N(R8)-CR9R10-A-O-E-R11, -N(R8)-CR9R12-A-D-E-R11, -N(R13)-CR9R10-A-D-E-R11 or -N(R8)-A-R15; A = CnH2n-; D = direct bond or O; E = CmH2m-; R8 = H, T or -CpH2p-R14; T = 1-4C alkyl; m, n, p = 0-5; R14 = phenyl, naphthyl or heteroaryl (all optionally substituted by 1-3 groups Q); Q = halo, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, T, OT, NMe2, SONH2, SO2Me or NHSO2Me; R9 = H or 1-6C alkyl; R10 = H, T or as for R14; R11 = phenyl, naphthyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, indazolyl, quinolyl, isoquinolyl, phthalazinyl, quinoxalinyl, quinazolyl or cinnolinyl (all optionally substituted by 1-3 groups Q); R12 = T or as for R14; R13 = -CpH2p-R14; R15 = 3-8C cycloalkyl; R2 = H or T; R3 = heteroaryl (optionally substituted by 1-3 groups Q); and R4 - R7 = H or Q. |
