发明名称 |
HYDROLYSIS OF [R(R*,R*)]-2-(4-FLUOROPHENYL)-(3,6-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE |
摘要 |
The present invention provides a process for preparing atorvastatin hemi-calcium from an atorvastatin ester derivative with calcium hydroxide. The process is conveniently incorporated into a process for preparing atorvastatin hemi-calcium from an acetonide protected, ester protected beta,delta-dihydroxy heptanoic acid precursor compound by a first acid hydrolysis step followed by base hydrolysis with calcium hydroxide. The latter process may be performed as a one-pot process. |
申请公布号 |
HRP20030454(A2) |
申请公布日期 |
2005.10.31 |
申请号 |
HR2003P000454 |
申请日期 |
2003.06.05 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
ETI ISHAI;REVITAL LIFSHITZ-LIRON;RAMI LIDOR-HADAS;VALERIE NIDDAM-HILDESHEIM |
分类号 |
A61K9/28;A61K9/50;C07B53/00;C07B61/00;C07D207/34;C07D209/24;C07D213/55;C07D215/14;C07D239/42;C07D403/06;C07D405/06 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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