| 摘要 |
FIELD: organic chemistry, medicine, oncology, pharmacy. ^ SUBSTANCE: invention relates to new heteroaryl derivatives, in particular, derivatives of quinoline of he general formula (I): wherein R, R1, R2 and R3 are similar or different and mean independently of one another hydrogen atom, linear or branched (C1-C8)-alkyl, halogen atom, aryl-(C1-C8)-alkoxy-group, aryl. Except for, R and R1 or R2 and R3 can form six-membered aromatic ring condensed with quinoline residue; X means oxygen atom; p, Q mean in each case -CH2-; X means nitrogen atom; n = 2; m = 0; R4 means phenyl or pyridyl. Also, invention relates to their pharmaceutically acceptable salts, in particular, acid-additive salts. Compounds are useful as antitumor agents. Also, invention describes a method for preparing compounds and medicinal agent based on thereof. ^ EFFECT: improved preparing method, valuable medicinal properties of compounds and agent. ^ 11 cl, 2 tbl, 13 ex
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