ORAL PHARMACEUTICAL PREPARATION WHICH INCLUDES A COMPOUND OF ANTI-ULCER ACTIVITY AND PROCEDURE FOR MAKING SAME.

摘要

COMPRISES AN INERT NUCLEUS; AN ACTIVE LAYER WHICH IS SOLUBLE OR DISINTEGRATES RAPIDLY IN WATER, OBTAINED FROM A SINGLE AQUEOUS OR HYDROALCOHOLIC SOLUTION-SUSPENTION WHICH INCLUDES : AN ACTIVE INGREDIENT OF ANTI- ULCEROUS ACTIVITY OF FORMULA I, II OR III, AND AT LEAST ONE EXCIPIENT; AND A GASTRO-RESISTANT OUTER COATING LAYER OBTAINED FROM A SOLUTION WHICH INCLUDES AN ENTERIC COATING POLYMER AND AT LEAST ONE EXCIPIENT.THE PROCEDURE IS CARRIED OUT BY 1) COATING OF THE INERT NUCLEI BY SPRAYING OF A SINGLE AQUEOUS OR HYDROALCOHOLIC SUSPENSION- SOLUTION; 2) DRYING OF THE ACTIVE LATER FORMED DURING THE SPRAYING OF THE PREVIOUS STAGE; AND 3) COATING OF THE CHARGED NUCLEI BY SPRAYING OF A SOLUTION WHICH INCLUDES AN ENTERIC COATING POLYMER WITH AT LEAST ONE EXCIPIENT IN ORDER TO OBTAIN A GASTRO-RESISTANT OUTER COATING LAYER.