METHOD FOR PRODUCING (Z)-1-PHENYL-1-DIETHYLAMINOCARBONYL-2-HYDROXYMETHYLCYCLOPROPANE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane being an intermediate for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hydrochloride by a simple process in a high yield more safely and inexpensively than a conventional production method. SOLUTION: The method for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane comprises reacting 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane with diethylamine in the presence of an alkali metal alkoxide. COPYRIGHT: (C)2006,JPO&NCIPI