| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention concerns area of gene engineering, virology and medicine. Nominally replicating carcinolytic improved recombinant of the adenovirus includes the basic virus, the modified hTERT promotor and immune regulatory genes. The virus preferably expresses immunostimulating factor GM-CSF in tumoral cells. Also the modified promotor, the pharmaceutical composition including virus, the way of reception of virus and its application is revealed. The invention can be used in medicine for treatment of tumours. ^ EFFECT: development of a virus which preferably expresses immunostimulating factor GM-CSF in tumoral cells. ^ 22 cl, 13 dwg, 2 tbl, 7 ex |
