发明名称 MULTI-PARTICULATE FORM OF MEDICAMENT, COMPRISING AT LEAST TWO DIFFERENTLY COATED FORMS OF PELLET
摘要 The invention relates to a multiparticulate drug form suitable for uniform release of an active pharmaceutical ingredient in the small intestine and in the large intestine, comprising at least two forms of pellets A and B which comprise an active pharmaceutical ingredient in the core and have different polymer coatings which determine the release of the active ingredient at different pH values, characterized in that pellet form A is provided with an inner polymer coating which enables continuous release of active ingredient, and has an outer enteric coating which rapidly dissolves above about pH 5.5, and pellet form B is provided with a polymer coating which, in the USP release test, releases less than 20% of the active ingredient at pH 6.8 in 6 hours and releases more than 50% of the active ingredient at pH 7.2 in 6 hours. The invention additionally relates to a process for producing the multiparticulate drug form and to the use of pellet forms A and B for producing the drug form.
申请公布号 PL201766(B1) 申请公布日期 2009.05.29
申请号 PL20010356962 申请日期 2001.03.09
申请人 ROEHM GMBH & CO.KG 发明人 BECKERT THOMAS;PETEREIT HANS-ULRICH;DRESSMAN JENNIFER;RUDOLPH MARKUS
分类号 A61K9/16;A61K9/20;A61K9/26;A61K9/50;A61K9/54;A61K9/58;A61K9/62;A61K31/573;A61K31/58;A61K31/606;A61K31/635;A61K47/32;A61K47/36;A61K47/38;A61P1/00 主分类号 A61K9/16
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