Medical devices having activated surfaces

摘要

Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members.

主权项

1. A method of preparing a medical device having an activated surface, the method comprising:
acid-treating at least a portion of a surface of a polymeric medical device to obtain hydrolysis; and attaching one or more click reactive members to the acid-treated surface of the medical device, wherein the click reactive members are selected from the group consisting of thiols, azides, alkynes, and alkenes.