发明名称 |
BICYCLOANILINE DERIVATIVE |
摘要 |
The invention relates to a compound of a general formula (I):
wherein A 1 and A 2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R 1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R 2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine. |
申请公布号 |
HRP20161536(T1) |
申请公布日期 |
2016.12.30 |
申请号 |
HR2016P001536T |
申请日期 |
2016.11.21 |
申请人 |
MSD K.K. |
发明人 |
Bamba, Makoto;Furuyama, Hidetomo;Niiyama, Kenji;Sakamoto, Toshihiro;Sunami, Satoshi;Takahashi, Keiji;Yamamoto, Fuyuki;Yoshizumi, Takashi |
分类号 |
C07D487/04;A61K31/522;A61K31/5415;A61K31/55;A61K31/553;A61K45/00;A61K45/06;A61P35/00;A61P43/00;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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