发明名称 |
DRUG DELIVERY COMPOSITIONS AND METHODS TARGETING P-GLYCOPROTEIN |
摘要 |
A composition having general structure (1); wherein the P-gp substrate is a substrate for P-glycoprotein; the linker is a biocompatible polymeric moiety; the drug-loaded carrier comprises a biocompatible framework carrying at least one drug; and the straight line shown in Formula (1) between the drug-loaded carrier and linker represents a first bond, and the straight line shown in Formula (1) between the linker and P-gp substrate represents a second bond. Also described herein are pharmaceutical compositions containing the above compositions, as well as methods for using these compositions for targeted delivery of a drug to cells expressing higher levels of P-glycoprotein compared to other cells in a mammal, for the treatment of various diseases or conditions, such as cancer and neurological conditions. |
申请公布号 |
US2016279263(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
US201314442550 |
申请日期 |
2013.11.14 |
申请人 |
CORNELL UNIVERSITY |
发明人 |
PUTNAM David;CRAWFORD Lindsey |
分类号 |
A61K47/48;A61K9/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
1. A composition having the following general structure: wherein: said P-gp substrate is a substrate for P-glycoprotein; said linker is a biocompatible polymeric moiety; said drug-loaded carrier comprises a biocompatible framework carrying at least one drug; and the straight line shown in Formula (1) between the drug-loaded carrier and linker represents a first bond, and the straight line shown in Formula (1) between the linker and P-gp substrate represents a second bond. |
地址 |
Ithaca NY US |