Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof

摘要

The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumor-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.

主权项

1. A compound selected from the group consisting of:
(a) 3-formamido-N-(heptadecan-9-yl)-2-hydroxybenzamide; (b) N-cyclopentadecyl-7-hydroxy-1H-indazole-6-carboxamide; (c) N-cyclopentadecyl-3-formamido-2-hydroxybenzamide; (d) N-cyclododecyl-3-formamido-2-hydroxybenzamide; (e) 3, 5-dichloro-N-cyclopentadecyl-2-hydroxybenzamide; (f) 3, 5-dichloro-N-decyl-2-hydroxybenzamide; (g) N-(3, 5-dichloro-2-hydroxyphenyl)undecanamide; (h) N-(4-(cyclopentadecylcarbamoyl)phenyl)-3-formamido-2-hydroxybenzamide; (i) N-(heptadecan-9-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxamide; (j) N-(3-(1-(heptadecan-9-yl)-1H-1,2,3-triazol-4-yl)-2-hydroxyphenyl)formamide; (k) N-(3-(1-cyclopentadecyl-1H-1,2,3-triazol-4-yl)-2-hydroxyphenyl)formamide; (l) N-cyclononyl-7-hydroxy-1H-indazole-6-carboxamide; (m) N-cyclononyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxamide; and (n) N-cyclopentadecyl-2-oxo-2, 3-dihydro-1H-benzo[d]imidazole-4-carboxamide, or a pharmaceutically acceptable salt or solvate of any one of (a)-(n).