| 摘要 |
<p>1351526α-Phenyl-cyclopentane acetic acidnortropine esters BOEHRINGER INGELHEIM GmbH 28 May 1971 [1 June 1970] 17926/71 Heading C2C Novel ester of the Formula I wherein R 1 is hydrogen or halogen or C 1-4 alkyl or alkoxy, R 2 is hydrogen, C 1-5 alkyl, C 3-6 cycloalkyl with the proviso that where R 1 is hydrogen and R 2 is methyl theα-phenyl-cyclopentane acetoxy moiety is # to the tropine moiety and acid addition and quaternary ammonium salts thereof may be prepared either by reacting a compound II where R 2 is other than hydrogen with an organic acid derivative III wherein Y is halogen, C 1-4 alkoxy or another group removable as an anion and if desired dealkylating the N-alkyl compound produced to give R 2 = H or by N-alkylating a compound I in which R 2 is hydrogen. Pharmaceutical compositions of I show anticholinergic activity when administered orally, parenterally or rectally with the usual excipients.</p> |
