METODO DE PREPARAR COMPUESTOS INTERMEDIOS PARA LA PRODUC- CION DE DERIVADOS DE AZUCAR DE PURINA.

摘要

1386584 Purine-sugars WELLCOME FOUNDATION Ltd (Burroughs Wellcome Co) 16 Feb 1972 [16 Nov 1970] 54503/70 Heading C2C The invention comprises a process for making compounds (II) by acylating (V) to give compounds (IV), condensing (IV) with (VI) to give compounds (III) and subjecting (III) to basic hydrolysis; (II) may be reduced to give compounds (I) (R1 is NH 2 , alkylamino or alkylthio, R2 is H, NH 2 or alkylamino provided that one of R1 and R2 is NH 2 or alkylamino, Z is a blocking group or one or two of the Z's is/are H and at least one of Y1 and Y2 is a protected group R3CON(A)- wherein A is H or alkyl and R3 is C 1 to C 20 alkyl and, when only one of Y1 and Y2 is R3CON(A), the other is R1 or R2: the reduction gives I where R1 is additionally SH or OH and R2 is additionally OH with the proviso still being applicable). Compounds (II) where R1 is NH 2 , lakylamino or alkylthio and R 2 is alkylamino are novel. The preparations of 2-amino-6-hydroxy-9-(#- D-arabinofuranosyl)purine and 2-hydroxy-6- amino-9-(#-D-arabinofuranosyl)purine are described.