| 摘要 |
<p>10 alpha -Hydroxy-11-desoxy-prostaglandin analogs of the PGE1 and PGE2 and PGF1 alpha and PGF2 alpha series, the 11-dehydro derivatives thereof as well as the 9,10-ketals in the PGF series, and methods of preparing same, 9-keto-10 alpha ,15 alpha -dihydroxyprosta-13-trans-enoic or 5-cis,13-trans-dienoic acid, 9 alpha ,10 alpha ,15 alpha -trihydroxyprosta-11,13-trans-dienoic or 5-cis, 11,13-trans-trienoic acid and 9 alpha ,10 alpha -isopropyli-denedioxy-15 alpha -hydroxyprosta-13-trans-enoic or 5-cis,13-trans-dienoic acid are representative of the class. Also included are the corresponding pharmaceutically acceptable, non-toxic esters, ethers and salts. These compounds possess prostaglandin-like activity and thus are useful in the treatment of mammals, where prostaglandins are indicated.</p> |
