| 发明名称 |
Fibronectin cradle molecules and libraries thereof |
| 摘要 |
The here described invention discloses a combination of a top and bottom loop binder library using the CD and the FG loops of a number of FnIII domains (FnIII) (e.g., FnIII7, FnIII10 and FnIII14) together with the surface exposed residues of the beta-sheet. The invention also pertains to a method of forming a library of FnIII domain polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. |
| 申请公布号 |
US9512199(B2) |
申请公布日期 |
2016.12.06 |
| 申请号 |
US201113813409 |
申请日期 |
2011.08.01 |
| 申请人 |
NOVARTIS AG;UNIVERSITY OF CHICAGO |
发明人 |
Loew Andreas;Vash Brian Edward;Koide Shohei;Wojcik John Bernard;Koide Akiko;Gilbreth Ryan Nicholas |
| 分类号 |
C07K14/78;C07K16/18;C07K16/40;C07K16/42 |
主分类号 |
C07K14/78 |
| 代理机构 |
|
代理人 |
Prince John T. |
| 主权项 |
1. A 10th fibronectin type III (FnIII10) domain-based cradle polypeptide capable of binding to a target molecule, wherein the cradle polypeptide comprises the sequence of SEQ ID NO: 44. |
| 地址 |
Basel CH |
