Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides

摘要

3-Quinuclidinol is reacted directly with a carboxylic acid anhydride, esp. acetic-, propionic- or butyric anhydride. Ester obtd. is opt. converted to a hydrohalide, by reaction with a hydrogen halide source (pref. HCl (gas), carboxylic acid halide, esp. corresp. to the anhydride used). Prods., e.g. 3-acetoxy-quinuclidine hydrochloride, have pharmacological properties, and can be prepd. on a large scale, in high yields.