发明名称 ANTI-KIR ANTIBODIES
摘要 Provided herein are compositions (e.g., killer cell immunoglobulin-like receptor (KIR)-targeting agents) that target a subset of T lymphocytes present in disease states (e.g., lupus and other autoimmune diseases) and methods of treating conditions and/or diseases therewith. In particular, anti-KIR antibodies, fragments thereof, or related compositions are provided for the treatment of conditions and/or diseases (e.g., lupus and other autoimmune diseases, atherosclerosis, etc.).
申请公布号 US2016272709(A1) 申请公布日期 2016.09.22
申请号 US201615043071 申请日期 2016.02.12
申请人 The Regents of the University of Michigan 发明人 Richardson Bruce
分类号 C07K16/28;A61K47/48;A61K39/395;A61K45/06 主分类号 C07K16/28
代理机构 代理人
主权项 1. A method of treating an autoimmune disease and/or atherosclerosis comprising administering to a subject an agent that selectively targets CD3+CD4+CD28+CD11ahiCD70+CD40LhiKIR+ T lymphocytes in the subject.
地址 Ann Arbor MI US