| 主权项 |
1. A method for producing a fiber wadding for filling bone defects by using an electrospinning apparatus that comprises a nozzle attached to a syringe, the method comprising:
applying a high positive voltage to the nozzle, which is attached to the syringe of the etectrospinning apparatus, so that an electric field is formed between the nozzle and a grounded plate disposed in a collector container of the electrospinning apparatus, and electrically charges a spinning solution filled in the syringe, thereby the spinning solution is emitted in a form of a fiber from a tip of the nozzle,
wherein the collector container contains a substantially pure ethanol liquid,wherein the spinning solution is prepared by dissolving a biodegradable polymer and a calcium compound in a substantially pure chloroform, wherein the biodegradable polymer is selected from a group consisting of polylactic acid and co-polymer of polylactic acid and polyglycolic acid,wherein the emitted fiber flies a predetermined distance toward the collector container such that the chloroform is evaporated from a surface of the fiber during flight from the nozzle to the collector container and enters into the ethanol liquid,wherein the fiber sinks in the ethanol liquid and deposits in the collector container to form a flocculent three dimensional fibrous structure; and collecting the fiber from the ethanol liquid in the collector container and drying the fiber to obtain the fiber wadding for filling bone defects,
wherein a bulk density of the fiber wadding, as measured in accordance with JIS L 1097, is from about 0.01 g/cm3 to about 0.1 g/cm3 . |
