发明名称 |
ANTIBODY THAT BINDS ERBB-2 AND ERBB-3 |
摘要 |
The invention relates among others to antibodies comprising a first antigen-binding site that binds Erb B-2 and a second antigen-binding site that binds Erb B-3. The antibodies can typically reduce a ligand-induced receptor function of Erb B-3 on a Erb B-2 and Erb B-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an Erb B-2, Erb B-3 or Erb B-2/3 positive tumor. |
申请公布号 |
SG11201607104R(A) |
申请公布日期 |
2016.09.29 |
申请号 |
SG11201607104R |
申请日期 |
2015.02.27 |
申请人 |
MERUS N.V. |
发明人 |
GEUIJEN, CECILIA ANNA WILHELMINA;DE KRUIF, CORNELIS ADRIAAN;THROSBY, MARK;LOGTENBERG, TON;BAKKER, ALEXANDER BERTHOLD HENDRIK |
分类号 |
C07K16/32 |
主分类号 |
C07K16/32 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|