Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof

摘要

The present invention relates to bispecific molecules that are immunoreactive to an activating receptor of a companion animal immune effector cell and to B7-H3, and to the use of such bispecific molecules in the treatment of cancer in companion animals.

主权项

1. A bispecific molecule comprising:
(A) a first epitope-binding domain, said first epitope-binding domain being capable of binding to an epitope of CD3 expressed on the surface of an immune effector cell of a companion animal, wherein said companion animal is a canine animal or a feline animal, and wherein said first epitope-binding domain comprises the amino acid sequences of:
(1) CDR1 (SEQ ID NO:93), CDR2 (SEQ ID NO:95) and CDR3 (SEQ ID NO:97) of the light chain of K9CD3-1 and CDR1 (SEQ ID NO:101), CDR2 (SEQ ID NO:103) and CDR3 (SEQ ID NO:105) of the heavy chain of K9CD3-1; or
(2) CDR1 (SEQ ID NO:109), CDR2 (SEQ ID NO:111) and CDR3 (SEQ ID NO:113) of the light chain of K9CD3-2 and CDR1 (SEQ ID NO:117), CDR2 (SEQ ID NO:119) and CDR3 (SEQ ID NO:121) of the heavy chain of K9CD3-2; and (B) a second epitope-binding domain, said second epitope-binding domain being capable of binding to an epitope of a cancer cell of said companion animal that expresses B7-H3.