<i>N</i>-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

摘要

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

主权项

1. A compound of the formula (IV):wherein:
R1 is H; R2 is H, aralkyl or heterocyclyl; T is alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl; and Z is an electron withdrawing group; or a pharmaceutically acceptable salt thereof.