Co-activation of mTOR and STAT3 pathways to promote neuronal survival and regeneration

摘要

Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

主权项

1. A method of promoting sustained survival in a lesioned mature neuron, sustained regeneration in a lesioned mature neuron, sustained compensatory outgrowth in a mature neuron, or a combination thereof, comprising:
contacting the neuron with an effective amount of an inhibitor of phosphatase and tensin homolog (PTEN) and an effective amount of an inhibitor of suppressor of cytokine signaling 3 (SOCS3) to thereby promote sustained survival, sustained regeneration, and/or sustained compensatory outgrowth of the neuron.