| 摘要 |
NEW MATERIAL:An amino sugar antibiotic G-367-2 having the following physicochemical properties, and a nontoxic acid addition salt thereof: Melting point 151- 155 deg.C. [alpha]D<24>=+159.8 deg. (C=1.0, water). Elemental analysis C, 50.41%; H, 7.92%; N, 15.16% (calculated: C, 50.99%; H, 8.33%; N, 15.64%). Molecular weight 447 (from mass spectrometry). Molecular formula C19H37N5O7. Soluble in water and methanol; insoluble in acetone, benzene, etc. Positive to the ninhydrin and KMnO4 reactions; negative to Elson-Morgan's and biuret reactions. White. Basic. USE:An antimicrobial agent against Gram-negative bacteria. PROCESS:Dactylosporangium thailandense G367 (FERM-P No.4840) is incubated, preferably in an aqueous culture medium, at 25-35 deg.C for 100-200hr, and the culture filtrate is separated and purified by the ion exchange resin method. |
